Classes > 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
Page last updated: 2024-08-05 12:15:51
5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
A lactam that is 2,3-dihydro-1,5-benzothiazepin-4(5H)-one in which positions 2 and 3 are substituted by 4-methoxyphenyl and acetoxy, respectively, while the hydrogen attached to the nitrogen is substituted by a 2-(dimethylamino)ethyl group.
ChEBI ID: 82814
Members (2)
| Member | Definition | Role |
|---|
| diltiazem | A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension. | diltiazem |
| ent-diltiazem | A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have R configuration. It is a cGMP-activated K+ channel blocker. | ent-diltiazem |
Research
Studies (5,993)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|
| pre-1990 | 2,083 (34.76) | 18.7374 |
| 1990's | 2,208 (36.84) | 18.2507 |
| 2000's | 1,043 (17.40) | 29.6817 |
| 2010's | 529 (8.83) | 24.3611 |
| 2020's | 130 (2.17) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|
| Trials | 1,073 (16.75%) | 5.53% |
| Reviews | 378 (5.90%) | 6.00% |
| Case Studies | 552 (8.62%) | 4.05% |
| Observational | 10 (0.16%) | 0.25% |
| Other | 4,394 (68.58%) | 84.16% |